Letter: Prolactin, bromocriptine, and haemostasis.
نویسندگان
چکیده
منابع مشابه
Prolactin concentrations in ovulatory but infertile women: treatment with bromocriptine.
We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility. The infertile patients were all ovulating regularly, and had been unsuccessfully treated with clomiphene and in some cases dydrogesterone and human menopausal gonadotrophin. Altho...
متن کاملMetabolite involvement in bromocriptine-induced prolactin inhibition in rats.
Bromocriptine (BCT) is a dopamine D2 receptor agonist used for the treatment of Parkinson's disease and hyperprolactinemic disorders. After oral administration, BCT is metabolized into mono- or dihydroxylated metabolites. To study how these metabolites influence parent drug pharmacodynamics, we administered BCT to rats intravenously (1 mg/kg i.v.) and orally (10 mg/kg p.o.) and measured the inh...
متن کاملEffects of estrogen and bromocriptine on prolactin levels and prolactin cells Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats: an experimental model of estrogen- dependent hyperprolactinemia
The present study was designed to assess the effects of bromocriptine, a dopamine agonist, on pituitary wet weight, number of immunoreactive prolactin cells and serum prolactin concentrations in estradioltreated rats. Ovariectomized Wistar rats were injected subcutaneously with sunflower oil vehicle or estradiol valerate (50 or 300 μg rat-1 week-1) for 2, 4 or 10 weeks. Bromocriptine (0.2 or 0....
متن کاملEffect of bromocriptine and pergolide on pituitary tumor size and serum prolactin.
Forty-two patients with elevated serum prolactin were treated in a randomized, open-label trial with the conventional ergot bromocriptine, or a new ergot pergolide. Before treatment, the patients underwent thorough endocrine evaluation and computed tomographic scan. All patients had prolactin levels greater than 25 ng/ml, and 27 patients had a pituitary mass. Follow-up studies performed after 6...
متن کاملEffect of prolactin and bromocriptine administration on epididymal function--a biochemical study in rats.
The pattern of androgen dependent enzyme activities of epididymis was studied after the administration of prolactin and bromocriptine in albino rats. Prolactin activated the glycogenolysis and hexose mono and diphosphate pathways, which would be essential for sperm maturation. But bromocriptine inhibited these activities of epididymis. Hence role of bromocriptine in decreasing epididymal functi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5978.307-a